Neuro-SysMed-seminar 27. mai 2026
Velkommen til Neuro-SysMed sine månadlege seminar! Bli med i auditoriet i Armauer Hansens Hus kl. 11:30–13:00 (lunsj fra 11:30–12:00). Emnet denne gongen blir presentert frå Neuro-SysMeds Drug Discovery-node.
Forelesar
Frå Neuro-SysMeds , med forelesarane Aurora Martinez og Kunwar Jung K.C.
Emne
Addressing complex I deficiency to alter Parkinson's disease course through innovative strategies
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Fristen er 22. mai kl. 11.00 dersom du vil vere med pÃ¥ lunsjen. Heilt fram til seminaret startar dersom ikkje. Â
Tid og stad
Stad: Auditoriet i Armauer Hansens Hus
±·Ã¥°ù: 27. mai 2026 kl. 11:30–13:00 (lunsj 11:30–12:00).
Samandrag
Parkinson’s disease (PD) therapies that halt or slow disease progression are urgently needed. This project targets mitochondrial complex I deficiency, a key feature in a subgroup of idiopathic PD, using an innovative cell-based drug-repurposing strategy. Screening of CNS-penetrant compounds identified a small-molecule compound (Hit1) as a promising candidate that increases mitochondrial respiratory chain protein levels, improves oxygen consumption, rescues rotenone-induced mitochondrial fragmentation, and stimulates mitochondrial biogenesis. These findings support further validation of Hit1 and related analogues as potential disease-modifying therapies for PD, with broader relevance for mitochondrial disorders in both the brain and peripheral tissues.