Neuro-SysMed Seminar May 27, 2026
Welcome to the Neuro-SysMed monthly seminar series! Join us at the auditorium in Armauer Hansens Hus at 11:30 - 13:00 (lunch from 11:30 - 12:00). The topic this time will be from Neuro-SysMed's Drug Discovery Node.
Speakers
From Neuro-SysMed's Drug Discovery Node, with the speakers Aurora Martinez and Kunwar Jung K.C.
Topic
Addressing complex I deficiency to alter Parkinson's disease course through innovative strategies
Registration
The deadline if you'd like to join the lunch is May 22 at 11.00Â
Where and when
Place: The auditorium in Armauer Hansens Hus
When: May 27, 2026, at 11:30 - 13:00 (lunch 11:30 - 12:00).
Abstract
Parkinson’s disease (PD) therapies that halt or slow disease progression are urgently needed. This project targets mitochondrial complex I deficiency, a key feature in a subgroup of idiopathic PD, using an innovative cell-based drug-repurposing strategy. Screening of CNS-penetrant compounds identified a small-molecule compound (Hit1) as a promising candidate that increases mitochondrial respiratory chain protein levels, improves oxygen consumption, rescues rotenone-induced mitochondrial fragmentation, and stimulates mitochondrial biogenesis. These findings support further validation of Hit1 and related analogues as potential disease-modifying therapies for PD, with broader relevance for mitochondrial disorders in both the brain and peripheral tissues.