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Affiliation

About the research group

For over 25 years, the Endocrine Medicine Research Group at the University of Bergen has been dedicated to understanding diseases related to the hormonal system.

Led by Professor Eystein Husebye, the group consists of researchers from diverse academic backgrounds 鈥 clinicians, endocrinologists, molecular biologists, cell biologists, bioinformaticians, pharmacists, and geneticists. This creates a strong interdisciplinary environment that combines experimental research with clinical studies and epidemiological analyses.

Our research spans from genetic mechanisms and mouse models to patient-centered studies and population data. The goal is to develop improved methods for diagnosing and treating endocrine diseases.

The group is based in modern laboratories on the 8th floor of the Laboratory Building at Haukeland University Hospital, with access to clinical facilities in both the medical and surgical departments.

Education

Education is a key part of our mission. Many students have completed both master鈥檚 and doctoral degrees within the group, and we place great emphasis on mentoring and developing new research talent.

Endocrine Medicine Research group
Photo: Geir Arne Sunde, Helse Bergen HF

Research

The research of the Endocrine Medicine group is patient-oriented, with active use of data and samples from national patient registries and biobanks. Technologies include advanced genetic analyses and single-cell methods such as 10x single-cell sequencing, flow cytometry, CyTOF, and tissue cytometry using Hyperion.

Our research focuses on understanding and improving care for endocrine autoimmune diseases and related hormonal disorders. From uncovering the earliest signs of autoimmunity to mapping genetic risk factors and immune mechanisms in Addison鈥檚 disease, we aim to clarify why these conditions develop and how they can be better treated. Projects span a wide range of topics, including autoimmune polyendocrine syndrome type 1 (APS-1), thyroid autoimmunity, premature ovarian failure, and primary hypoaldosteronism. We also investigate hormonal regulation, ultradian rhythms, and metabolic consequences of autonomous cortisol secretion. Through registry-based studies, clinical trials like the Cortad drug study, and innovative approaches to personalized therapy, our goal is to improve diagnosis, treatment, and long-term outcomes for patients worldwide.

Research activities are organized into four thematic nodes, each led by experts in the field. Individual projects are presented below.

  • Pathogenesis of Endocrine Autoimmunity
    Led by Professor Anette Wolff and Researcher Bergithe Oftedal
  • Clinical Studies of Endocrine Autoimmunity
    Led by Associate Professor Marianne 脴ksnes
  • Adrenal Tumors
    Led by Postdoctoral Fellow Grethe Ueland and Dr. Marianne Grytaas
  • Endocrine Surgery
    (Also part of the research group for endocrine neck surgery)
    Led by Professor Kerstin Lorenz and Associate Professor Katrin Brauckhoff

We also offer various autoantibody analyses related to endocrine autoimmunity and are world leaders in dynamic multiplex profiling of steroid hormones.

Registries and Research centres

The group has led the KG Jebsen Center for Autoimmune Diseases and manages the . Registries for adrenal tumors and primary hyperaldosteronism have also been established.

In addition, the group coordinates EndoTrain, a Horizon Europe Doctoral Training Network focused on digital endocrinology, and hosts the DRIV center for early ovarian insufficiency and autoimmune diseases, a leading research hub dedicated to understanding and innovating treatment for autoimmune fertility disease.

Collaboration

Endocrine Medicine maintains extensive collaborations at the local, national, and international levels. We have built a comprehensive national network on adrenal diseases, with representatives from all Norwegian health trusts.

Our international partnerships are particularly strong, notably with:

  • Karolinska Institutet (Sweden)
  • Weizmann Institute of Science (Israel)
  • University of Oxford (United Kingdom)

These collaborations have led to several high-profile publications, including:

  • Nature (2023)
  • Nature Communications (2021)
  • Nature Immunology (2016)
  • Immunity (2015)

Through Professor Husebye, the group has coordinated two major EU-funded projects:

  • FP7-EurAdrenal
  • H2020-Ultradian

Our international standing is further exemplified by invited review articles in:

  • New England Journal of Medicine (2018)
  • The Lancet (2021)

Alumni

Graduated PhD-students

2025 - "Copy Number Variation Analyses in Autoimmune Addison鈥檚 Disease and Diabetes"

2024 - "Hypoparathyroidism in Norway"

2024 聽-聽"Autoimmune primary adrenal insufficiency 鈥 autoantibodies and cell regeneration".

2023 -聽"Clues to Diagnosis and Clinical Outcomes in Autoimmune Addison鈥檚 Disease".

2023 - "Immune regulatory mechanisms in endocrine autoimmune disorders"

2023 -聽"Epidemiology and etiology of primary ovarian insuffciency"

2020听 -聽"Functional characterization of genetic risk factors in autoimmune Addison鈥檚 disease"

2019听- 鈥淚mproved diagnostic workup of hyper- and hypocortisolism鈥

2019听 - "Exploring and redefining Autoimmune polyendocrine syndrome type 1".

2018听聽- 芦Primary aldosteronism in Western Norway 鈥 studies of diagnostic approach and treatment outcome禄

2016 聽- "Immuno-endocrine interactions in autoimmune Addison鈥檚 disease"

2015 -聽芦Genetics of autoimmune Addison鈥檚 disease and congenital adrenal hyperplasia禄.

2015听聽-聽聽鈥滱utoimmunity and viral immunity in Addison鈥檚 disease鈥.

2014听-聽"New corticosteroid assays and their applications in adrenal insufficiency and obesity".

2014听聽- 芦Glucocorticoid Treatment and Quality of Life in Addison鈥檚 disease禄

2013 -聽Congenital Adrenal Hyperplasia in Adults: Epidemiological, Genetic, Clinical and Endocrine Features of CYP21A2 Deficiency in Norway.

2012听聽-聽鈥淎utoimmune polyendocrine syndrome type I 鈥搉ovel diagnostic assays and immune regulation鈥.

2010听聽- "Addison鈥檚 disease in Norway"

2010听 -聽鈥滿olekyl忙rgenetiske og immunologiske aspekter av autoimmun Addisons sykdom og autoimmunt polyendokrint syndrom type I鈥.

2009听聽- 鈥滳ellular immunity in autoimmune Addison鈥檚 disease 鈥 T cell responses to steroid cytochrome P450 21-hydroxylase鈥.

2005 - "Immunological perspectives of autoimmune polyendocrine syndromes and cancer"

2004 -聽"Studies of autoimmune adrenocortical failure and polyendocrine syndromes"

2003听聽-聽鈥淓pidemiological and clinical perspectives on Addison鈥檚 disease鈥

Graduated master students

2023 MSc Mathias Lundberg

2023 MSc Dorsa Iraji

2022 MSc聽Emina Majcic

2022 MSc Abtin Tari

2022 MSc聽Adrianna聽Jebrzycka

2022 MSc Ifunanya Nwakwuo

2020 MSc Solveig Henriette Einevoll

2020 MSc Thea Sj酶gren

2019 MSc Marte Heimli

2019 MSc Amund Berger

2013 MSc Sepideh Mustafavi

2012 MSc Anja Kjellesvik-Kristiansen

2010 MSc Andr茅 Madsen

2010 MSc Alexander Hellesen

2010 MSc Ragnhild Stenberg Berg

2008 MSc Martha Schei Hynne

People

Group manager
Group members
Postdoctors
PhD-students
Technichians and administrative staff