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The research of Ivar Hordvik is focused on components of the adaptive immune system in fish. A long term goal is to broaden the spectrum of well characterized molecules and develop molecular tools that can be used to study immune responses during experiments with vaccines and pathogens in fish.

After teleost fish made a separate branch on the phylogenetic tree significant differences have been introduced between fish and mammals, both with respect to primary sequence of corresponding molecules, and the introduction of new molecules by gene duplications. An example of this is the evolution of the immunoglobulins: Whereas IgM has been evolutionarily stable and maintained the primordial structure in all jawed vertebrates the IgD gene has been evolutionarily labile and has been subjected to many internal duplications and deletions. A newly discovered gene, encoding an isotype named IgT/IgZ appears to be specific for teleost fish. On the other hand, IgG, IgE, and IgA are isotypes present in mammals, but not in fish.

Several findings the last years have shown that studies of the immune system in fish still offers surprises. It is plausible to assume that improved knowledge on the function and ontogeny of immune components in fish will aid experimental design of future vaccination trials and interpretation of results. Delivery of vaccines across mucosal surfaces of fish would obviously be an advantage and boost the profitability of the aquaculture industry. Development of new reagents for identification of immune cells and for monitoring immune responses is also an issue which has been addressed by vaccine companies as well as many researchers.

Author(s): Overgard, AC; Hordvik, I; Nerland, AH, et al.
Source: FISH & SHELLFISH IMMUNOLOGY   Volume: 27   Issue: 6   Pages: 707-713   Published: 2009

Author(s): Moore, LJ; Dijkstra, JM; Koppang, EO, et al.
Source: FISH & SHELLFISH IMMUNOLOGY   Volume: 26   Issue: 1   Pages: 10-18   Published: 2009

Author(s): Haugarvoll, E; Bjerkas, I; Nowak, BF, et al.
Source: JOURNAL OF ANATOMY   Volume: 213   Issue: 2   Pages: 202-209   Published: 2008

Author(s): Liu, Y; Moore, L; Koppang, EO, et al.
Source: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY   Volume: 32   Issue: 1   Pages: 26-35   Published: 2008

Author(s): Jordal, AEO; Hordvik, I; Pelsers, M, et al.
Source: COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY   Volume: 145   Issue: 2   Pages: 147-158   Published: OCT 2006

Author(s): Hevroy, EM; Jordal, AEO; Hordvik, I, et al.
Source: AQUACULTURE   Volume: 252   Issue: 2-4   Pages: 453-461   Published: MAR 10 2006

Author(s): Dijkstra, JM; Somamoto, T; Moore, L, et al.
Source: MOLECULAR IMMUNOLOGY   Volume: 43   Issue: 5   Pages: 410-419   Published: FEB 2006

Author(s): Morrison, RN; Koppang, EO; Hordvik, I, et al.
Source: VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY   Volume: 109   Issue: 3-4   Pages: 297-303   Published: FEB 15 2006

Author(s): Van Do, T; Elsayed, S; Florvaag, E, et al.
Source: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY   Volume: 116   Issue: 6   Pages: 1314-1320   Published: DEC 2005

Author(s): Olsvik, PA; Lie, KK; Jordal, AEO, et al.
Source: BMC MOLECULAR BIOLOGY   Volume: 6   Article Number: 21   Published: NOV 17 2005

Author(s): Moore, LJ; Somamoto, T; Lie, KK, et al.
Source: MOLECULAR IMMUNOLOGY   Volume: 42   Issue: 10   Pages: 1225-1234   Published: JUN 2005

Author(s): Van Do, T; Hordvik, I; Endresen, C, et al.
Source: MOLECULAR IMMUNOLOGY   Volume: 42   Issue: 3   Pages: 345-353   Published: FEB 2005

Author(s): Fischer, U; Dijkstra, JM; Kollner, B, et al.
Source: FISH & SHELLFISH IMMUNOLOGY   Volume: 18   Issue: 1   Pages: 49-60   Published: JAN 2005

Author(s): Koppang, EO; Haugarvoll, E; Hordvik, I, et al.
Source: JOURNAL OF FISH DISEASES   Volume: 28   Issue: 1   Pages: 13-22   Published: JAN 2005

Author(s): Hordvik, I; Torvund, J; Moore, L, et al.
Source: MOLECULAR IMMUNOLOGY   Volume: 41   Issue: 5   Pages: 553-559   Published: JUL 2004

Author(s): Koppang, EO; Haugarvoll, E; Hordvik, I, et al.
Source: VETERINARY PATHOLOGY   Volume: 41   Issue: 2   Pages: 122-130   Published: MAR 2004

Author(s): Koppang, EO; Bjerkas, E; Bjerkas, I, et al.
Source: SCANDINAVIAN JOURNAL OF IMMUNOLOGY   Volume: 58   Issue: 1   Pages: 9-14   Published: JUL 2003

Author(s): Van Do, T; Hordvik, I; Endresen, C, et al.
Source: MOLECULAR IMMUNOLOGY   Volume: 39   Issue: 10   Pages: 595-602   Published: JAN 2003

Author(s): Hordvik, I; Berven, FS; Solem, ST, et al.
Source: MOLECULAR IMMUNOLOGY   Volume: 39   Issue: 5-6   Pages: 313-321   Published: OCT 2002

Author(s): Hordvik, I
Source: MOLECULAR IMMUNOLOGY   Volume: 39   Issue: 1-2   Pages: 85-91   Published: SEP 2002

Author(s): Solem, ST; Hordvik, I; Killie, JEA, et al.
Source: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY   Volume: 25   Issue: 5-6   Pages: 403-417   Published: JUN-JUL 2001

Author(s): Hatten, F; Fredriksen, A; Hordvik, I, et al.
Source: FISH & SHELLFISH IMMUNOLOGY   Volume: 11   Issue: 3   Pages: 257-268   Published: APR 2001

Author(s): Van Do, T; Hordvik, I; Endresen, C, et al.
Source: SCANDINAVIAN JOURNAL OF IMMUNOLOGY   Volume: 50   Issue: 6   Pages: 619-625   Published: 1999

Author(s): Hordvik, I; Thevarajan, J; Samdal, I, et al.
Source: SCANDINAVIAN JOURNAL OF IMMUNOLOGY   Volume: 50   Issue: 2   Pages: 202-210   Published: AUG 1999

Author(s): Krossoy, B; Hordvik, I; Nilsen, F, et al.
Source: JOURNAL OF VIROLOGY   Volume: 73   Issue: 3   Pages: 2136-2142   Published: MAR 1999

Author(s): Hordvik, I
Source: IMMUNOLOGICAL REVIEWS   Volume: 166   Pages: 153-157   Published: DEC 1998

Author(s): Nilsen, F; Endresen, C; Hordvik, I
Source: JOURNAL OF EUKARYOTIC MICROBIOLOGY   Volume: 45   Issue: 5   Pages: 535-543   Published: SEP-OCT 1998

Author(s): Hordvik, I; Lindstrom, CD; Voie, AM, et al.
Source: MOLECULAR IMMUNOLOGY   Volume: 34   Issue: 8-9   Pages: 631-639   Published: JUN 1997

Author(s): Hordvik, I; Jacob, ALJ; Charlemagne, J, et al.
Source: IMMUNOGENETICS   Volume: 45   Issue: 1   Pages: 9-14   Published: 1996

Author(s): Lindstrom, CDV; VanDo, T; Hordvik, I, et al.
Source: SCANDINAVIAN JOURNAL OF IMMUNOLOGY   Volume: 44   Issue: 4   Pages: 335-344   Published: OCT 1996

Author(s): Hordvik, I.
Source: Aquaculture and Fisheries Management   Volume: 25   Issue: 1   Pages: 47-53   Published: 1994

Author(s): Lie, O.; Slettan, A.; Lingaas, F., et al.
Source: Animal Biotechnology   Volume: 5   Issue: 1   Pages: 33-45   Published: 1994

Author(s): GRIMHOLT, U; HORDVIK, I; FOSSE, VM, et al.
Source: IMMUNOGENETICS   Volume: 37   Issue: 6   Pages: 469-473   Published: FEB 1993

Author(s): HORDVIK, I; GRIMHOLT, U; FOSSE, VM, et al.
Source: IMMUNOGENETICS   Volume: 37   Issue: 6   Pages: 437-441   Published: FEB 1993

Author(s): HORDVIK, I; VOIE, AM; GLETTE, J, et al.
Source: EUROPEAN JOURNAL OF IMMUNOLOGY   Volume: 22   Issue: 11   Pages: 2957-2962   Published: NOV 1992